Searchable abstracts of presentations at key conferences in endocrinology

ea0044p2 | Adrenal and Steroids | SFEBES2016

Dynamic changes in nephrine levels with acclimatisation reflect acquisition of heat tolerance

Stacey Mike , Britland Sophie , Delves Simon , Burnett Anne , Fallowfield Joanne , Brett Stephen , Allsopp Adrian , Woods David

Background: Heat acclimatisation (HA) describes phenotypic changes (decreased heart rate, HR; lower core body temperature, Tc) resulting from exposure to a hot environment. Heat tolerance with HA may reflect altered adrenocortical and autonomic nervous responses to heat stress, though evidence for sympathetic downregulation is lacking. Methodological limitations to further investigation (e.g. with direct catecholamine measurement) could be overcome by assaying the catecholamin...

ea0044p74 | Clinical biochemistry | SFEBES2016

Characterising susceptibility to heat illness by plasma copeptin measurement

Stacey Mike , Delves Simon , Woods David , Britland Sophie , Fallowfield Joanne , Allsopp Adrian , Brett Stephen

Background: Work in a hot environment can cause elevated core body temperature (Tc), circulatory insufficiency and death from Exertional Heat Illness (EHI). Failure to undergo successful heat acclimatisation (HA) is seen in ~5% of otherwise healthy volunteers and may lead to significant EHI, but pathways to severe illness remain poorly understood. Copeptin, a glycopeptide co-secreted with the pituitary hormone arginine vasopressin, reflects osmotic and cardiovascular stress an...

ea0034s5.1 | Endocrine consequences of major trauma | SFEBES2014

The immune-endocrine mechanisms of trauma-induced sarcopenia

Hampson Peter , Foster Mark , Taylor Angela , Bentley Conor , Fallowfield Joanne , Midwinter Mark , Arlt Wiebke , Lord Janet

Advances in trauma care have improved survival resulting in more severely injured individuals surviving to enter the trauma care pathway. A significant threat to recovery is now the dysregulated immune response to injury. The hyperinflammatory response of the innate immune system (SIRS), combined with immunoparesis, leads to complications such as multi-organ failure and sepsis. Moreover, recovery from trauma is significantly affected by age, which may be due to changes in the ...

ea0044p138 | Neuroendocrinology and pituitary | SFEBES2016

Copeptin as a marker of cardiovascular strain during occupational heat stress

Stacey Mike , Woods David , Macconnachie Lee , Britland Sophie , Delves Simon , Allsopp Adrian , Brett Stephen , Fallowfield Joanne , Boos Christopher

Background: Regulation of core body temperature (Tc) can cause significant cardiovascular strain, leading to impaired performance, incapacitation and occupational hazard during work in the heat. Where continuous Tc and heart rate (HR) monitoring is not possible (e.g. during firefighting or on military operations), safer working could result from intermittent sampling of an integrated measure of physiological strain.Aims: To assess the relationship betwee...